Monday 26 May 2014

Long term use of painkiller may decrease sexual function

Long term use of painkillers like nonsteroidal anti-inflammatory drugs (NSAIDS) that reduce inflammation and pain may cause sexual dysfunction like erectile dysfunction. Approximately 30% of the male patients taking NSAIDs reported moderate or severe erectile dysfunction. If you are taking NSAIDs and feel that your erectile function decreased then you must consult doctor.  

Reference: 
Gleason JM, Slezak JM, Jung H, Reynolds K, Van den Eeden SK, Haque R, Quinn VP, Loo RK, Jacobsen SJRegular nonsteroidal anti-inflammatory drug use and erectile dysfunction.  2011;185(4):1388-93. 

Saturday 24 May 2014

Cinnamon may increase sexual function of aged male

Sexual function in aged male decreases due to endothelial dysfunction (impairment of penile blood vessel and penile smooth muscle to relax) and increase in activity of bad enzymes like arginase and Rho-kinase. Cinnamon may be helpful in increasing sexual function by inhibiting action of bad enzymes and increasing penile endothelial smooth muscle. 

As per a recently published article, methanol extract of Cinnamon increased sexual function of 2 year aged rat. Fifty percent of the aged rats had lost sexual function and another fifty percent of the rats had decreased sexual function. Cinnamon extract increased sexual function of aged rats those had low sexual function and increased sexual function of a rat that was unresponsive to sexual stimuli.  

Reference:

Goswami SK, Inamdar MN, Jamwal R, Dethe SEfficacy of Cinnamomum cassia Blume. in age induced sexual dysfunction of rats.  2013 Dec;5(4):148-53.

Cinnamon can increase sexual function


Cinnamon can increase sexual function. It has been included in Ayurvedic formulation for increasing sexual function. In a recent study methanol extract of Cinnamon increased sexual function of rats at 100 mg/kg body weight. Cinnamon inhibits enzyme called arginase and Rho-kinase those are responsible for erectile dysfunction (difficulty in penile erection for satisfactory sexual activity).

References:

Goswami SKPandre MKJamwal RDethe SAgarwal AInamdar MN.Screening for Rho-kinase 2 inhibitory potential of Indian medicinal plants used in management of erectile dysfunction.  2012 18;144(3):483-9. 

Goswami SK, Inamdar MN, Jamwal R, Dethe SEffect of Cinnamomum cassia Methanol Extract and Sildenafil on Arginase and Sexual Function of Young Male Wistar Rats 2014 Apr 23. doi: 10.1111/jsm.12535. [Epub ahead of print]


Monday 5 May 2014

Long term use of antacid may decrease its efficiency

Acids secreted by stomach helps to kill harmful bacteria in gastrointestinal (GI) tract apart from digesting food. Long term use of antacid may decrease production of acid or increase the pH in GI tract. This situation can favor development of certain harmful bacteria in GI tract.These bacteria can spread other diseases and release endotoxin that can worsen ulcer.  Therefore, do not use antacids for long time without consulting doctor.    

Fish oil can reduce stomach ulcer

Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid from fish oil was reported to have protective effect on NSAIDs induced gastric ulcer in rats.  Indomethacin (3, 10, and 30 mg/kg) induced gastric ulcer as a dose dependent manner when administered orally. DHA (3, 10, 30mg/kg) administered orally 2 hours before indomethacin treatment protected gastric damage significantly. The gastroprotective effect was comparable to that of omeprazole (30 mg/kg, an antacid medicine) administered 30 minute before NSAID treatment. The effect of treatment on ulcer was tested 3 hour after NSAID treatment. The gastroprotective effect could be partially due to decreasing level of LTB4 gastric levels that was increased by NSAID treatment.  

Source:
Pineda-Pen˜a EA, Jime´nez-Andrade JM, Castan˜eda-Herna´ndez G, AE Cha´ vez-Pin˜a.  Docosahexaenoicacid, an omega-3 polyunsaturated acid protectsagainst indomethacin-inducedgastricinjury. Pulmonary, gastrointestinal and urogenital pharmacology. European Journal of Pharmacology 2012; 697: 139–143. 

Tuesday 29 April 2014

Dealing with gastric ulcer

Imbalance between acid production in stomach and protection of stomach by mucosal layer (and prostaglandin concentration in stomach) primarily result in gastric ulcer. Bacterial infection (like infection by Helicobacter pylori), alcohol, smoking, stress can cause and aggravate existing ulcer. Nonsteroidal anti-inflammatory drugs (NSAIDs) those decrease the pain by reducing production of prostaglandins (a type of lipid compounds that protect stomach) cause ulcer when used for a long time. Better sanitation can reduce bacterial infection. Stop / decrease drinking alcohol and smoking cigarette for ulcer to heal faster with medicine. Decrease stress by performing meditation, relaxing and talking to people who can help you to come out from stressful life. Medicine used in ulcers either decrease the production of gastric acid or neutralize the acid due to its alkaline nature. Antibiotics are also prescribed if bacterial infection in stomach is confirmed. Molecules/chemicals having similar structure like prostaglandin are also marketed for the treatment of gastric ulcer.  

Taking care of skin

When skin is exposed to sunlight, vitamine D is produced. Vitamine D is essential for absorption of calcium from food and calcium is required for formation of teeth, bone etc. Calcium also has many other functions. Best time to expose your skin to sunlight is morning. You can go out without the fear of tanning your skin. In winter season, apply cold cream on skin to prevent it from drying. If you skin is more sensitive to skin, you may have to apply cold cream two times. When going out in day time or playing outside (under son) for long time use sun-screen spray or ointment to prevent damaging effect of ultra-violate ray of sun.  Sun-screen spray or ointment can prevent formation of vitamine D by preventing/decreasing the exposure of skin to sun-light. Be care full if you go for tattoo. You may develop hepatitis (liver disease) or AIDS if infected needles were used. Development of unusual spot on skin may indicate development of any disease like leprosy or tuberculosis. In this case visit a doctor. 

Saturday 19 April 2014

Taking care of ear

Listening loud noise regularly may decrease hearing capacity. If you are travelling by flight, train etc. regularly then consider using ear plug. Improper use of ear plug also may damage ear. Do not enter match stick or similar thing for cleaning ear as it may damage ear. Cotton swab may pack some amount of the ear-wax while removing little of it. If required use ear removal kit, put few drop of it in the ear before sleeping.  The solution will melt ear-wax and remove it. Use of ear phone for long time may promote bacterial growth in ear. Everyday clean your ear with wet towel.

Sunday 6 April 2014

Take care of eye

Read book from safe distance (approximately 30 cm from eyes). Reading books from a shorter or longer distance may strain your eyes. Do not sit continuously in front of book/laptop/desktop. Take a break of 5 minutes after 1 hour reading. If your are wearing spectacle (as per doctors recommendation), then check your vision once in a year. Clear your spectacle regularly as dust deposited on it may hinder your vision and there may be bacterial growth around the deposited dirt. If you get scratches on lens of spectacle, then change the lens otherwise it may strain your eye. Do not touch your eyes with dirty hands and you may get infection. If dust fall on eye, then wash your eye, do not rub as it may damage your eye.  

Friday 21 March 2014

Exercise increases sexual function

Exercise reported increases sexual function and motivation in human and experimental animals. It may be due to increase in fitness and level of reproductive hormones. Even, exercise training improved erectile response in type 1 diabetic rats those exhibit lower erectile function. Recovery in erectile function was observed in aging hypertensive and normotensive rats using exercise and controlling diets.




How safe is online viagra?

I receive spam mail regarding availability of cheap viagra (sildenafil) on line. Many people get similar mail for increasing sexual function. Is online viagra safe? A study was conducted by Campbell et al. to determine the quality of online viagra. The researchers collected viagra samples from 22 sources selling viagra online for quality control tests. Maximum (77%) of the tested medicine were counterfeit and contained less active ingredient (30-50% of label claim).  Counterfeits did not provide product information leaflets, and appropriate safety warnings. It is very essential to check the credibility of source before buying viagra and other generic medicines online. 

Source:
[Campbell N, Clark JP, Stecher VJ, and Goldstein I. Internet-ordered Viagra (sildenafil citrate) is rarely genuine. J Sex Med 2012;9:2943–2951.] It was found that 

Counterfeit phosphodiesterase type 5 inhibitors pose significant safety risks