Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid
from fish oil was reported to have protective effect on NSAIDs induced gastric
ulcer in rats. Indomethacin (3, 10, and 30
mg/kg) induced gastric ulcer as a dose dependent manner when administered
orally. DHA (3, 10, 30mg/kg) administered orally 2 hours before indomethacin
treatment protected gastric damage significantly. The gastroprotective effect
was comparable to that of omeprazole (30 mg/kg, an antacid medicine) administered
30 minute before NSAID treatment. The effect of treatment on ulcer was tested 3
hour after NSAID treatment. The gastroprotective effect could be partially due
to decreasing level of LTB4 gastric levels that was increased by NSAID
treatment.
Source:
Pineda-Pen˜a EA, Jime´nez-Andrade
JM, Castan˜eda-Herna´ndez G, AE Cha´ vez-Pin˜a. Docosahexaenoicacid, an omega-3 polyunsaturated
acid protectsagainst indomethacin-inducedgastricinjury. Pulmonary,
gastrointestinal and urogenital pharmacology. European Journal of Pharmacology 2012;
697: 139–143.
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